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9034329 |
Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
The present invention provides methods of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprising (a) preparing an antibody or antibody fragment;... |
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9034330 |
Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said... |
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9023621 |
Methods for identifying and isolating cells expressing a polypeptide
The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific... |
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9005921 |
Polynucleotides encoding IL-31 monoclonal antibodies
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the... |
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9005924 |
Acceptor framework for CDR grafting
The present invention relates to an antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a particularly well suited antibody acceptor... |
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8999324 |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with... |
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8993228 |
Antibody binding to envelope protein 2 of hepatitis C virus and method for identifying genotype of hepatitis C virus using the same
The present invention provides an antibody that specifically binds to envelope protein 2 of HCV of genotype 2a but does not immunologically react with envelope protein 2 of HCV of genotype 1a. |
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8993261 |
Antibodies for the detection of integrin complexes in FFPE material
The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in... |
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8981071 |
Human anti-B7RP1 neutralizing antibodies
This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also... |
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8975384 |
Tag peptide and use thereof
The present invention provides a tag peptide comprising an amino acid sequence represented by the following formula (I): X1-Tyr-X2-Gly-Gln-X3 (I) (wherein X1, X2 and X3 are the same or different... |
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8968736 |
Human antibodies to GFRα3 and methods of use thereof
The present invention provides antibodies that bind to human GFRα3 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind... |
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8969024 |
Compositions and methods comprising binding proteins for adalimumab
Compositions and methods comprising proteins that bind specifically to adalimumab are disclosed herein. Adalimumab is a monoclonal antibody specific for the cytokine TNF-α and was developed to... |
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8969529 |
Methods and compositions based on shiga toxin type 2 protein
The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include... |
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8956830 |
Methods of cell culture
Polypeptide preparations having target levels of glycans, and methods of producing such polypeptide preparations using DMSO, are described. |
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8945867 |
Process for producing polypeptide
The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which... |
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8945857 |
Methods of isolating cells and generating monoclonal antibodies
The invention provides methods for isolating cells, particularly antibody-secreting cells that have a high likelihood of secreting antibodies specific for a desired antigen for the purpose of... |
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8945873 |
Polynucleotides encoding Notch receptor antibodies
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides... |
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8945870 |
DNA encoding an anti-system ASC amino acid transporter 2 (ASCT2) antibody
An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred... |
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8945547 |
Notch1 receptor antibodies and methods of treatment
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,... |
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8945874 |
Polynucleotides encoding NOTCH1 receptor antibodies
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,... |
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8940963 |
Production of hetero-oligomeric proteins in plants
Process of producing in a plant, in plant tissue, or in plant cells a hetero-oligomeric protein comprising at least a first and a second protein subunit, said process comprising expressing in... |
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8926982 |
Reagents and methods for detecting influenza virus proteins
Two universally conserved sequences from influenza type A neuraminidases were identified by large scale sequence analysis then chemically modified and conjugated to carrier proteins to generate... |
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8916152 |
S100A4 antibodies and therapeutic uses thereof
The invention relates to antibodies against S100A4, methods for the preparation of these antibodies, pharmaceutical compositions comprising these antibodies, and therapeutic and diagnostic uses... |
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8911731 |
Monoclonal antibodies specific for beta-amyloid x-37 and uses thereof
The present invention provides monoclonal antibodies which specifically recognize the shorter Aβ peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the Aβ-peptide... |
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8906649 |
Antibodies binding human collagen II
The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using... |
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8865398 |
Combination hepatitis C virus antigen and antibody detection method
An in vitro method that allows detection of hepatitis C by detecting hepatitis C virus (HCV) core protein and antibodies to HCV core protein (anti-core antibodies) in a single assay is provided.... |
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8865162 |
Monoclonal antibodies against HPV proteins
Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by... |
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8865874 |
Hapten compound and antibody
The present invention is a compound having a structure represented by the following formula (1): and an antibody to BSH obtained by using the compound as a hapten and using a complex of the hapten... |
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8859218 |
In situ detection of early stages and late stages HPV infection
Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by... |
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8859234 |
Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having... |
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8859278 |
Fully human hybridoma fusion partner cell lines
Certain aspects of the present invention are directed to new fully human fusion partner cell lines called human Karyochi cells, and to methods for making them. Human Karyochi cells are then fused... |
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8835188 |
Screening assays and methods
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with... |
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8835187 |
Screening assays and methods
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with... |
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8828670 |
Method for the production of proteins and peptides
The invention relates to a method for producing monomeric or dimeric proteins or peptides containing internal or external disulfide bonds, comprising the following steps: a) a cell-free lysate,... |
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8809017 |
IRES mediated multicistronic vectors
This invention relates to nucleic acid molecules comprising at least one nucleic acid sequence encoding for a peptide or protein of interest, at least one nucleic acid sequence encoding for a... |
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8772049 |
Screening assays and methods
Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with... |
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8765413 |
Cell cultivation process
This invention relates to a cell culture process for the production of polypeptides in mammalian CHO cells characterized by one or more temperature and pH shifts which are adjusted in respect to... |
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8758753 |
Ganglioside associated recombinant antibodies and the use thereof in the treatment of tumors
The present invention is related to the obtaining of modified antibodies by means of DNA recombinant technology from the murine monoclonal antibody P3 (MAb P3), produced by the hybridoma cell line... |
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8759489 |
Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same
The present invention relates to an antibody that recognizes a first antibody, the antibody specifically recognizing one of a free first antibody and an antigen-binding first antibody. More... |
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8753632 |
Antibodies to modified human IGF-1/E peptides
High-specificity antibodies can distinguish between modified (e.g, hIGF-1/Ea 3mut) and endogenous wild-type human IGF-1 proteins. These antibodies have little or no cross-reactivity with hIGF-1 or... |
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8741586 |
Antibodies against HER2 truncated variant CTF-611
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the... |
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8735098 |
Methods and composition for secretion of heterologous polypeptides
The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous... |
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8728761 |
Production of glycosylated polypeptides in micro algae
Transformed microalgae capable of expressing glycosylated polypeptides and methods for producing said transformed microalgae and producing glycosylated polypeptides. |
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8716031 |
Method for quantification of antigen-specific canine IgE
Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which... |
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8685669 |
Nucleic acid molecules encoding humanized antibody molecules specific for IL-31
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the... |
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8673593 |
Antibodies to alpha-synuclein
The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically... |
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8642275 |
Immunological tests for the presence of bacteria which make use of antibodies obtained using a specific method
The use of a bacterial antigen obtained from bacterial cells in the production of antibodies for immunological assays for detecting bacterial cells. |
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8637258 |
Compositions and methods for regulating NK cell activity
The present invention relates to a method of producing an antibody that cross-reacts with multiple KIR2DL polypeptides and neutralizes the inhibitory activity of such polypeptides. |
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8632779 |
S. aureus polypeptides and antibodies
The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to... |
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8628772 |
Surface protein (HBsAg) variant of the hepatitis B virus
The invention relates to sequences of a novel variant of the Hepatitis B surface antigen (HBsAg) and to methods for detecting, in patient samples, nucleic acids, antigens, and antibodies directed... |